Bernard and Bianca, of the Rescue Aid Society (a mouse organization) receive a message in a bottle from an orphaned girl who appears to have been kidnapped by Madame Medusa, a selfish woman who has no qualms about using children for her own purposes. The two mice go off to Devil's Bayou to attempt to rescue the little girl.

Cody, a boy from Mugwomp Flats responds to a distress call about a trapped giant Golden Eagle called Marahute. Freeing her, he gains a close friendship with the bird. However, Cody is soon abducted by the murderous poacher, Percival McLeach, who is after that bird which is of a highly endangered species and therefore an extremely profitable quarry.