Jared Leto gained 60 pounds to play Mark David Chapmen, in the movie, Chapter 27, and was wheel-chair bound as a result.
http://www.list.co.uk/article/7345-wheelch...und-jared-leto/
[Edit: Here are some youtube clips:
http://www.youtube.com/watch?v=pwj3VHjrQ3I
http://www.youtube.com/watch?v=FZQGsuF1E48 ]
He went from this:

To this:

All I can say is that he better lose the weight, because as soon as they invent that machine that allows you to switch bodies with someone, I'm kidnapping him!